Antismoking drug still recommended to Canadians despite side effects and US advisory
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چکیده
منابع مشابه
The US Food and Drug Administration Cardiorenal Advisory Panel and the drug approval process.
New chemical entities developed by the pharmaceutical industry as potentially useful drugs undergo extensive preclinical evaluation followed by clinical trials to evaluate efficacy and safety in human subjects. In the United States, the Food and Drug Administration (FDA) is charged with evaluating requests from pharmaceutical sponsors for approval to market new drugs or to expand indications fo...
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In this article, we present the case of a 12-year-old female child who complained of bilateral temporal and frontal headache for 2 to 3 months with nausea and vomiting. Physical examination revealed right-sided sixth cranial nerve palsy and papilledema in ophthalmoscopy. To find the cause of increased intracranial pressure, the patient underwent brain imaging and brain MRI showed no abnormality...
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The complexity of antiretroviral therapy, coupled with the lifelong duration of treatment, presents the need for extensive management of drug interactions and adverse effects. This article includes an extensive discussion of drug interactions involving antiretroviral agents and other medications (eg, antibiotics, oral contraceptives, H2 antagonists, and lipid-lowering agents) commonly used in i...
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Previous analysis of systems pharmacology has revealed a tendency of rational drug design in the pharmaceutical industry. The targets of new drugs tend to be close with the corresponding disease genes in the biological networks. However, it remains unclear whether the rational drug design introduces disadvantages, i.e. side effects. Therefore, it is important to dissect the relationship between...
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From St. Jude Children’s Research Hospital and the University of Tennessee Colleges of Pharmacy and Medicine, Memphis (W.E.E.); and Washington University Medical School, St. Louis (H.L.M.). Address reprint requests to Dr. Evans at St. Jude Children’s Research Hospital, 332 N. Lauderdale St., Memphis, TN 381010318, or at [email protected]. t is well recognized that different patients resp...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2009
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.090114